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Genetic causes of male infertility | Dr N Layyous

Genetic causes of male infertility


Is infertility hereditary or are there other causes?

Infertility is defined as the inability to have children after a full year of marital relationship, without the use of protection methods, and it is possible that infertility has genetic causes, and genetic causes of infertility are found in men more than women, but there may be other causes of infertility other than Genetic factors, and in many cases the diagnosis of infertility may be unjustified

The main causes of infertility in men:

1- Occlusion of the vessels carrying sperm, or testicular and varicocele injuries.

2- Problems with erection and ejaculation.

3- Sperm abnormalities, and genetic problems.

4- Hormonal problems and genetic defects.

Causes of Klinefelter syndrome

A large percentage of families suffered from some genetic diseases, the most important of which is the genetic problem of infertility resulting from a defect in the chromosomes that carry the genetic characteristics of the person. The most common disease is a disease called "Klinefelter's syndrome" as a result of late childbearing, where the mother's and father's abilities to form normal gametes have been weakened due to their being affected by age, environment and the various diseases they have had over time.

In most cases, people with Klinefelter syndrome have the ability to have children, but in a small percentage.


In Klinefelter syndrome, a specific genetic defect occurs in men, where a man is supposed to have an X chromosome and a Y chromosome, but in this syndrome, a man has 2 X chromosomes and one Y chromosome, and there are many types of this increase in the X chromosome, as it is possible for a man to have a chromosome It is possible that this extra chromosome is just a coincidence that is found only in the male reproductive cells, and the birth of a male child at an old age is the most common reason for not having Kellefelter syndrome.

This syndrome causes the testicles to develop abnormally, which leads to a low level of testosterone in the man, and a decrease in the number of sperm, which leads to infertility.

Symptoms of Klinefelter syndrome

Symptoms of this syndrome may appear in males since childhood, or symptoms may be delayed until puberty, and some may not know that they have this condition from the ground up, and the symptoms of this syndrome in newborn males are the failure of the testicles to fall into the scrotum, or the slowness in learning to sit Crawling, talking, or being overly calm, but these symptoms are not necessarily a sign of the syndrome.

Dr. Najeeb Layyous F.R.C.O.G

Consultant of Obstetrics and Gynecology and Infertility

Last Update: 2023-09-11 09:17:07
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